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COVERAGE AS OF
NOVEMBER 2019:
457,209SAFETY ALERTS
14,803TARGETS & GENES
14,200DRUGS & BIOLOGICS
7,109ADVERSE EVENTS
COVERAGE AS OF NOVEMBER 2019:
457,209
SAFETY ALERTS
14,803
TARGETS & GENES
14,200
DRUGS & BIOLOGICS
7,109
ADVERSE EVENTS
WEEKLY REPORTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Nov 2-5
European Congress of Oncological Gynecology (ESGO) Annual Meeting, Athens
Nov 2-6
International Society of Pharmacoeconomics and Outcomes Research (ISPOR) Europe 2019, Copenhagen
IN PROGRESS
Oct 31-Nov 2
The 33rd Annual North American Cystic Fibrosis Conference, Nashville
Oct 30-Nov 3
89th Annual Meeting of the American Thyroid Association, Chicago
IN PROGRESS
Oct 27-31
XXIV World Congress of Neurology, Dubai
Oct 25-30
American College of Gastroenterology (ACG) 2019, San Antonio
Oct 24-27
20th Annual Fall Scientific Meeting of SMSNA, Nashville
Oct 23-26
48th Annual Meeting of the Child Neurology Society, Charlotte
Oct 23-26
51st Congress of the International Society of Paediatric Oncology (SIOP), Lyon
Oct 19-23
17th International Congress of Immunology, IUIS 2019, Beijing
IN PROGRESS
Oct 19-23
CHEST Annual Meeting 2019, New Orleans
Oct 19-23
Neuroscience 2019, Chicago
Oct 19-23
The Anesthesiology Annual Meeting 2019, Orlando
Oct 19-23
United European Gastroenterology Week (UEGW), Barcelona
Oct 17-20
39th Congress of the Société Internationale d'Urologie, Athens
Oct 16-19
13th Congress of the European Society of Gynecology, Vienna
Oct 15-19
American Society of Human Genetics 69th Annual Meeting (ASHG) 2019, Houston
Oct 14-19
AACAP's 66th Annual Meeting, Chicago
Oct 13-17
70th AALAS National Meeting, Denver
Oct 12-16
ASRM 2019 Scientific Congress & Expo, Philadelphia
Oct 11-14
9th Trends in Medical Mycology (TIMM), Nice
Oct 11-15
American Academy of Ophthalmology (AAO) 2019 Annual Meeting, San Francisco
Oct 9-13
28th European Academy of Dermatology and Venerology (EADV) Congress, Madrid
Oct 2-6
IDWeek 2019, Washington
Oct 1-5
24th International Annual Congress of the World Muscle Society (WMS), Copenhagen
Sep 28-Oct 2
European Respiratory Society International Congress (ERS) 2019, Madrid
Sep 27-Oct 1
ESMO 2019 Congress, Barcelona
Sep 26-Oct 28
EORTC CLTF 2019, Athens
Sep 26-28
NAFLD Summit 2019, Seville
Sep 23-27
North American Congress of Clinical Toxicology (NACCT) 2019, Nashville
Sep 23-26
Safety Pharmacology Society Annual Meeting 2019, Barcelona
Sep 22-26
17th IATDMCT 2019 Congress, Foz do Iguacu
Sep 22-26
2019 International Congress of Parkinson's Disease and Movement Disorders, Nice
Sep 21-24
World Congress of Gastroenterology (WCOG) 2019, Istanbul
Sep 20-22
13th Annual Conference of the International Liver Cancer Association (ILCA 2019), Chicago
Sep 20-25
World Sleep 2019 Congress, Vancouver
Sep 19-21
58th Annual European Society for Paediatric Endocrinology (ESPE) Meeting, Vienna
Sep 19-21
IGCS Annual 2019 Meeting, Rio de Janeiro
Sep 18-21
49th Annual European Society for Dermatologic Research (ESDR) Meeting, Bordeaux
Sep 17-21
13th European Paediatric Neurology Society (EPNS) Congress, Athens
Sep 17-Oct 20
17th European Congress of Toxicologic Pathology, Cologne
Sep 16-20
55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona
Sep 13-16
HFSA 23rd Annual Scientific Meeting, Philadelphia
Sep 12-15
17th International Myeloma Workshop (IMW), Boston
Sep 11-14
14th International Skeletal Dysplasia Society (ISDS) Meeting, Oslo
Sep 11-13
European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Annual Meeting, Stockholm
Sep 11-14
SOHO 2019 Annual Meeting, Houston
Sep 11-15
The Retina Society, 52nd Scientific Meeting, London
Sep 7-Oct 10
The IASLC 20th World Conference on Lung Cancer (#WCLC2019), Barcelona
Sep 5-8
19th European Society of Retina Specialists Congress (EURETINA), Paris
THE NEW OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (457,209 curated alerts as of November 2019). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
14,803TARGETS & GENES
14,200DRUGS & BIOLOGICS
457,209SAFETY ALERTS
7,109ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of November 2019, OFF-X covers More than 14,803 targets, 14,200 drugs and biologics, 7,109 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 457,209 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to request more information on the OFF-X APIs
OFF-X
NEWS