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COVERAGE AS OF
APRIL 2020:
584,916SAFETY ALERTS
14,876TARGETS & GENES
15,181DRUGS & BIOLOGICS
7,933ADVERSE EVENTS
COVERAGE AS OF APRIL 2020:
584,916
SAFETY ALERTS
14,876
TARGETS & GENES
15,181
DRUGS & BIOLOGICS
7,933
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
FREE ACCESS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Mar 28-30
ACC.20 Together With World Congress of Cardiology, Chicago
IN PROGRESS
Mar 28-31
ENDO 2020, Endocrine Society's Annual Meeting, Washington
IN PROGRESS
Mar 26-29
ISN World Congress of Nephrology (WCN) 2020, Abu Dhabi
IN PROGRESS
Mar 25-27
25th Congress of the European Association of Hospital Pharmacists (EAHP), Gothenburg
IN PROGRESS
Mar 25-29
National Kidney Foundation 2020 Spring Clinical Meetings, New Orleans
IN PROGRESS
Mar 18-21
American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2020 Annual Meeting, Houston
Mar 16-18
The 93rd Annual Meeting of the Japanese Safety Pharmacological Society, Yokohama
IN PROGRESS
Mar 15-19
SOT 2020 - 59th Annual Meeting and ToxExpo, Anaheim
Mar 13-16
American Academy of Allergy, Asthma & Immunology (AAAAI) 2020 Annual Meeting, Philadelphia
Mar 11-13
17th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease, Barcelona
IN PROGRESS
Mar 8-11
Conference on Retroviruses and Opportunistic Infections (CROI) 2020, Boston
Mar 4-8
29th Annual Conference of Asian Pacific Association for the Study of the Liver, Bali
Feb 27-29
ACTRIMS Forum 2020, Florida
Feb 26-Mar 1
American Academy of Pain Medicine (AAPM 2020) 36th Annual Meeting, National Harbor
Feb 19-21
International Stroke Conference 2020, Los Angeles
Feb 19-23
Transplantation and Cellular Therapy Meetings of ASBMT and CIBMTR (TCT 2020), Orlando
Feb 16-19
49th Critical Care Congress, Orlando
Feb 14-16
3rd Pan American Parkinson’s Diseases and Movement Disorders 2020, Miami
Feb 14-16
ESMO Summit Africa 2020, Cape Town
Feb 13-15
ASCO Genitourinary Cancers Symposium 2020, San Francisco
Feb 13-14
ESMO Preceptorship on Breast Cancer 2020, Cape Town
IN PROGRESS
Feb 12-15
15th Congress of ECCO, Vienna
Feb 5-7
13th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD) 2020, The Hague
Jan 23-25
ASCO Gastrointestinal Cancers Symposium 2020, San Francisco
Jan 23-25
Crohn's & Colitis Congress 2020, Austin
Jan 17-22
Winter Clinical Dermatology Conference 2020, Hawaii
THE NEW OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (584,916 curated alerts as of April 2020). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
0
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
14,876TARGETS & GENES
15,181DRUGS & BIOLOGICS
584,916SAFETY ALERTS
7,933ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of April 2020, OFF-X covers More than 14,876 targets, 15,181 drugs and biologics, 7,933 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 584,916 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to request more information on the OFF-X APIs
OFF-X
NEWS