The OFF-X portal uses cookies. You can change your cookie preferences in your browser settings. If you agree to the use of cookies, please click OK. For more information on our use of cookies, please see our Cookie Policy.
OK
COVERAGE AS OF
JANUARY 2020:
508,187SAFETY ALERTS
14,846TARGETS & GENES
14,928DRUGS & BIOLOGICS
7,489ADVERSE EVENTS
COVERAGE AS OF JANUARY 2020:
508,187
SAFETY ALERTS
14,846
TARGETS & GENES
14,928
DRUGS & BIOLOGICS
7,489
ADVERSE EVENTS
WEEKLY REPORTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Dec 12-15
Asian Pacific Digestive Week (APDW) 2019, Kolkata
Dec 11-14
ESMO Immuno-Oncology Congress 2019, Geneva
Dec 10-14
San Antonio Breast Cancer Symposium (SABCS) 2019, San Antonio
Dec 8-11
58th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), Orlando
Dec 7-10
61st American Society of Hematology (ASH) Annual Meeting and Exposition, Orlando
Dec 6-10
American Epilepsy Society (AES) Annual Meeting 2019, Baltimore
Dec 4-7
12th Clinical Trials on Alzheimer's Disease (CTAD) Conference, San Diego
Nov 30-Dec 3
19th FIGIJ World Congress of Paediatric and Adolescent Gynaecology (WCPAG19), Melbourne
Nov 22-24
ESMO Asia 2019 Congress, Singapore
Nov 21-23
27th Annual Meeting of the European Charcot Foundation, Baveno
Nov 20-24
24th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology (SNO), Phoenix
Nov 16-18
American Heart Association's (AHA) 2019 Scientific Sessions, Philadelphia
Nov 14-17
11th European Multidisciplinary Congress on Urological Cancers (EMUC19), Vienna
Nov 13-16
Connective Tissue Oncology Society (CTOS) Annual Meeting 2019, Tokyo
Nov 11-13
Society for Endocrinology BES 2019, Brighton
Nov 8-12
AASLD, The Liver Meeting 2019, Boston
Nov 8-13
American College of Rheumatology ACR/ARP Annual Meeting 2019, Atlanta
Nov 7-11
American College of Allergy, Asthma, and Immunology (ACAAI) Annual Scientific Meeting 2019, Houston
Nov 6-9
17th European AIDS Conference (EACS) 2019, Basel
Nov 6-10
34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019), Maryland
Nov 5-10
American Society of Nephrology (ASN) Kidney Week 2019, Washington
Nov 2-5
European Congress of Oncological Gynecology (ESGO) Annual Meeting, Athens
Nov 2-6
International Society of Pharmacoeconomics and Outcomes Research (ISPOR) Europe 2019, Copenhagen
Oct 31-Nov 2
The 33rd Annual North American Cystic Fibrosis Conference, Nashville
Oct 30-Nov 2
50th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union), Hyderabad
Oct 30-Nov 3
89th Annual Meeting of the American Thyroid Association, Chicago
Oct 27-31
XXIV World Congress of Neurology, Dubai
Oct 26-30
31st EORTC-NCI-AACR symposium (ENA 2019), Boston
Oct 25-30
American College of Gastroenterology (ACG) 2019, San Antonio
Oct 24-27
20th Annual Fall Scientific Meeting of SMSNA, Nashville
Oct 23-26
48th Annual Meeting of the Child Neurology Society, Charlotte
Oct 23-26
51st Congress of the International Society of Paediatric Oncology (SIOP), Lyon
THE NEW OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (508,187 curated alerts as of January 2020). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
14,846TARGETS & GENES
14,928DRUGS & BIOLOGICS
508,187SAFETY ALERTS
7,489ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of January 2020, OFF-X covers More than 14,846 targets, 14,928 drugs and biologics, 7,489 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 508,187 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to request more information on the OFF-X APIs
OFF-X
NEWS