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COVERAGE AS OF
JUNE 2020:
704,101SAFETY ALERTS
14,903TARGETS & GENES
17,349DRUGS & BIOLOGICS
8,637ADVERSE EVENTS
COVERAGE AS OF JUNE 2020:
704,101
SAFETY ALERTS
14,903
TARGETS & GENES
17,349
DRUGS & BIOLOGICS
8,637
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
FREE ACCESS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
May 29-31
ASCO Virtual Scientific Program 2020, Virtual Meeting
IN PROGRESS
May 23-24
ESMO Breast Cancer Virtual Meeting 2020, Virtual Meeting
IN PROGRESS
May 15-18
American Urological Association (AUA) Annual Meeting 2020, Washington
IN PROGRESS
May 12-15
23rd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT 2020), Virtual Meeting
IN PROGRESS
May 3-7
ARVO 2020 Annual Meeting, Baltimore
May 2-5
Digestive Disease Week (DDW) 2020, Chicago
Apr 30-May 2
75th Anniversary Meeting of Society of Biological Psychiatry (SOBP 2020), New York
Apr 27-28
AACR Virtual Annual Meeting I 2020, Virtual Meeting
Apr 25-May 1
Annual Meeting American Academy of Neurology (AAN) 2020, Toronto
Apr 24-27
69th ACOG Annual Clinical and Scientific Meeting 2020, Seattle
Apr 23-25
45th Annual Regional Anesthesiology and Acute Pain Medicine Meeting 2020, San Francisco
Apr 22-25
40th Annual Meeting and Scientific Sessions ISHLT, Montreal
Apr 21-24
AMCP Managed Care & Specialty Pharmacy Annual Meeting 2020, Houston
Apr 20-22
British Society for Rheumatology Annual Conference 2020, Glasgow
Apr 18-21
30th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Paris
IN PROGRESS
Mar 28-30
ACC.20 Together With World Congress of Cardiology, Chicago
Mar 28-31
ENDO 2020, Endocrine Society's Annual Meeting, Washington
Mar 28-31
SGO Annual Meeting on Women's Cancer 2020, Toronto
Mar 26-29
ISN World Congress of Nephrology (WCN) 2020, Abu Dhabi
Mar 25-27
25th Congress of the European Association of Hospital Pharmacists (EAHP), Gothenburg
Mar 25-29
National Kidney Foundation 2020 Spring Clinical Meetings, New Orleans
Mar 18-21
American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2020 Annual Meeting, Houston
Mar 17-21
ACMG Annual Clinical Genetics Meeting 2020, San Antonio
Mar 17-20
American Burn Association 52nd Annual Meeting, Orlando
Mar 16-18
The 93rd Annual Meeting of the Japanese Safety Pharmacological Society, Yokohama
Mar 15-19
SOT 2020 - 59th Annual Meeting and ToxExpo, Anaheim
Mar 13-16
American Academy of Allergy, Asthma & Immunology (AAAAI) 2020 Annual Meeting, Philadelphia
Mar 11-13
17th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease, Barcelona
Mar 10-14
67th Society for Reproductive Investigation (SRI) Annual Scientific Meeting 2020, Vancouver
Mar 8-11
Conference on Retroviruses and Opportunistic Infections (CROI) 2020, Boston
THE NEW OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (704,101 curated alerts as of June 2020). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
0
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
14,903TARGETS & GENES
17,349DRUGS & BIOLOGICS
704,101SAFETY ALERTS
8,637ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of June 2020, OFF-X covers More than 14,903 targets, 17,349 drugs and biologics, 8,637 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 704,101 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to request more information on the OFF-X APIs
OFF-X
NEWS